Multi-Organ Failure

🔬Causes & Risk Factors

• 1Multi-organ failure most commonly develops as a consequence of severe sepsis
• 2in which an overwhelming infection triggers a dysregulated inflammatory response that damages blood vessels and organs throughout the body. Other major causes include severe trauma with significant blood loss
• 3extensive burns
• 4prolonged episodes of shock from any cause
• 5and complications following major surgery. The underlying mechanism generally involves impaired blood flow and oxygen delivery to organs combined with a harmful
• 6body-wide inflammatory cascade that damages tissue directly.