End-Stage Organ Failure

📖What is End-Stage Organ Failure?

End-stage organ failure refers to the irreversible, final phase of decline in a vital organ such as the heart, lungs, kidneys, or liver, where the organ can no longer sustain the body's basic physiological needs despite maximal medical therapy. It is typically the culmination of a chronic disease process such as heart failure, chronic obstructive pulmonary disease, chronic kidney disease, or cirrhosis that has progressed over months to years. Patients experience escalating symptom burden, frequent hospitalizations, and a shift in care focus from curative treatment toward comfort and quality of life. It affects multiple organ systems simultaneously in advanced cases, compounding fatigue, breathlessness, and functional decline.

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