Complex Regional Pain Syndrome

🔬Causes & Risk Factors

• 1The exact mechanism is not fully understood
• 2but complex regional pain syndrome is thought to arise from an abnormal response of the peripheral and central nervous systems to an injury
• 3involving dysregulated inflammatory signaling
• 4abnormal nerve fiber sensitization
• 5and disrupted communication with the autonomic nervous system that controls blood vessels and sweat glands. It typically follows a specific triggering event
• 6such as a fracture
• 7surgery
• 8sprain
• 9or prolonged immobilization
• 10though the severity of the initial injury does not always correlate with the severity of the resulting syndrome. Psychological stress is thought to be an aggravating rather than a primary causal factor.